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    On February 12, 2010, the Board of Patent Appeals and Interferences (BPAI) of the U. Patent and Trademark Office (USPTO) issued an decision invalidating Pfizer’s broad claim for treating male erectile dysfunction (ED). The four granted reexaminations were merged and the fifth request was denied as it did not add anything to the merged reexamination. Chemically, Cialis® (pyrazino-pyrido-indole-diones) and Levitra® (2-phenyl-imidazotriazinones) belong to different classes of compounds. The first reexamination was ordered sua sponte by the USPTO, which in itself is a rather unusual occurrence, while the other three were requested by Lilly ICOS (manufacturers and marketers of the competitor impotence drug Cialis®) and Bayer (manufacturer and marketer of another competitor impotence drug Levitra®). Certainly, if claim 24 were found to be valid, it would appear that administering any selective c GMP PDEV inhibitor, including compounds such as Cialis® and Levitra® would infringe this claim. 6,469,012, entitled “Pyrazolopyrimidinones for the Treatment of Impotence” issued on October 22, 2002 and assigned to Pfizer, Inc. This patent was subject to four ex parte reexamination proceedings and five reexamination requests. Since 2003, this litigation has been stayed pending the decision on the reexamination(s). As yet there remains no word on an appeal by Pfizer. Immediately after the decision was handed down Pfizer spokesman, Chris Loder, said “the decision has no effect on Pfizer’s patent claims relating to Viagra.” Loder also said Pfizer would appeal the decision. 08/549,792, filed March 4, 1996, which is the national phase of PCT/EP94/01580, filed May 13, 1994, and which claims benefit to GB Patent Application No. The patent claims cover the first commercially successful male impotence drug — Viagra®. The claim at issue in the merged reexamination proceeding was: Claim 24. However, they are also selective c GMP PDEV inhibitors so would fall under the broadly written claim 24. doxycycline yeast infection treatment Comfort Endurance™ Suspension Sleeves are made of a higher grade neoprene than most of the Neoprene suspension sleeves available on the market. It is easy to distinguish the higher quality when you take time to feel an Endurance™ suspension sleeve and compare it to others. It has a much smoother feel, and is a tougher and more durable neoprene material than most others. Endurance™ sleeves also have a rugged outer nylon cover. Every Endurance™ suspension sleeve is manufactured using an intensive blind stitching and gluing process that greatly reduces seam failure. With three styles and two stock colors available, there is an Endurance™ sleeve that is right for everybody! Custom colors are also available for an additional charge.

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