fluoxetine Prozac paroxetine Paxil venlafaxine Effexor escitalopram Lexapro For the fist time in its history the FDA recently approved an SSRI antidepressant, Brisdelle, also named Paxil (paroxetine), for the treatment of menopausal hot flashes.(1) The clinical trial which generated the data for FDA approval was funded by Noven Pharmaceuticals. Instead of using hormone replacement as a treatment for menopausal hot flashes, mainstream medicine docs will sometimes prescribe SSRI antidepressants off-label.(22-26) Off-label use means that the SSRI drug has not been FDA approved for treatment of menopausal symptoms of hot flashes. The lead author of the study was James A Simon, an MD who disclosed financial relationships with Noven and thirty other pharmaceutical companies. (2-4) The FDA approved the paroxetine drug against the vote of an FDA advisory committee. They voted 10-4 against approval in a meeting held March 2013. (5-17) Click here for a transcript of the FDA meeting.: Transcript_FDA_Advisory _MArch_2013. Mary Carol Jennings made a statement against approval to the FDA Advisory Committee because the drug carries adverse effects which outweigh any potential benefit. Simon’s Brisdelle (paroxetine) clinical trial started with about 10 hot flashes per day. After 12 weeks, those on paroxetine had 4 hot flashes per day compared to 5-6 for the placebo group. propranolol withdrawal Please register to participate in our discussions with 2 million other members - it's free and quick! Some forums can only be seen by registered members. I was told that it takes about two weeks to kick in-so I am trying to be VERY patient. Believe me it was much worse than any hot flash and I've not been the same since. After you create your account, you'll be able to customize options and access all our 15,000 new posts/day with fewer ads. I was on HRT for 2 years tried to go off but the flashes came back. Once I realized what it was for I realized they had given me a long term drug for a short term problem and that is when I started asking questions before ever taking another drug. I was told that it takes about two weeks to kick in-so I am trying to be VERY patient. Since I only use once in a while, when I do, the hot flashes INCREASE for a few days before they get better. But it is hard being patient when you have at least a dozen (maybe more) hot flashes A DAY!!!! Make sure you have a ceiling fan over your bed and you can make it. If you are taking either of these, how well did it work for you? Went back on HRT for a year and ended up with a blood clot, DVT, in my calf. Once I tried to get off the Paxil, I realized you just can't stop taking it... My opinion, there are lot better medications for HRT than this long term drug that you will have problems getting off of. Since I only use once in a while, when I do, the hot flashes INCREASE for a few days before they get better. But it is hard being patient when you have at least a dozen (maybe more) hot flashes A DAY!!!! I don't like it but I must confess that it worked-somewhat. Not to mention the nasty ones in the middle of the night that wake you up-and then you are tired the next day. Okay, after a month on the Brisdelle I saw zero, or at best, a very minimal change in the severity and frequency of the flashes. This is an anti-seizure med that has been found to help many women w/flashes and most people don't get side effects except dizziness or sleepiness the first week. I have to find a solution because this is really impacting my life. So I'm off the HRT and just about dying from the flashes, many many times per day drenched in sweat. (at the time they put me on it, there was nothing on the internet explaining the side effects or withdrawls when you try to quit.. I don't like it but I must confess that it worked-somewhat. Not to mention the nasty ones in the middle of the night that wake you up-and then you are tired the next day. Cat I always said that I didn't want to go on any HRTs because of all the nasty stuff associated with them-cancer, blood clots, strokes, heart attacks, etc. Not enough of an improvement to justify taking the med. So today is my first day and they are ramping up my dose this week. One of my biggest triggers is being out in the heat/sun, so I'm basically housebound on any day over 85 degrees. Just look it up and see what everybody else says about it and look up "brain zaps".)I always said that I didn't want to go on any HRTs because of all the nasty stuff associated with them-cancer, blood clots, strokes, heart attacks, etc. But then the hot flashes were relentless-not to mention the moodiness, the weight gain, etc. If I try to golf, or hike, or even BBQ in the yard, I am beet red and soaked/dripping wet from head to foot. But then the hot flashes were relentless-not to mention the moodiness, the weight gain, etc. Seriously I look like I just stepped from the shower fully clothed. After the blood clot episode, I know I can't ever go back on HRT. Propecia dangerous What is paroxetine Brisdelle, and how does it work mechanism of action?; What brand. Quick GuideMenopause & Perimenopause Symptoms, Signs. antabuse side effects with alcohol Dec 20, 2017. These are the most effective treatments for hot flashes, and can also help. will go a long way towards minimizing the symptoms of menopause. Aug 12, 2015. Women taking Paroxetine had a mean weekly reduction of 28.9 fewer hot flashes compared with reduction of 19.0 fewer hot flashes for women. Your doctor can usually diagnose hot flashes based on a description of your symptoms. Your doctor might suggest blood tests to check whether you're in menopausal transition. The most effective way to relieve the discomfort of hot flashes is to take estrogen, but taking this hormone carries risks. If estrogen is appropriate for you and you start it within 10 years of your last menstrual period or before age 60, the benefits can be greater than the risks. Medications such as antidepressants and anti-seizure drugs also might help reduce hot flashes, although they're less effective than hormones. Discuss the pros and cons of various treatments with your doctor. If hot flashes don't interfere with your life, you probably don't need treatment. There are a number of different treatment options to consider if menopause is disrupting your life. The most common symptoms include hot flashes, night sweats, mood problems, trouble sleeping, and vaginal dryness. Treatment with estrogen and progesterone, called combination hormone replacement therapy (HRT), can be prescribed for women who still have their uterus, if they have moderate to severe symptoms of menopause. Estrogen alone is the prescribed regimen for women who have had a hysterectomy (no longer have their uterus). These are the most effective treatments for hot flashes, and can also help with vaginal dryness and mood problems. Hormonal patches, creams, gels, and vaginal rings are alternatives to the traditional pills, depending on the symptoms. Treatment is usually started before age 60 and taken up to 5 years. These women include those with breast or uterine (endometrial) cancer, blood clots, liver disease, heart disease stroke, women who may be pregnant, or who have undiagnosed vaginal bleeding. If you are unable or do not want to take hormones, there are treatments that your doctor can prescribe to alleviate some of the symptoms of menopause. If you have vaginal dryness without hot flashes, you can try vaginal estrogen. How quick does paroxetine work on hot flushes Hot flash - Wikipedia, Treating Menopause Symptoms Vaginal Dryness, Hot Flashes, and. Duloxetine nursing implications Doctors aren't sure how Paxil paroxetine works to treat hot flashes associated with menopause, although research shows that hot flashes decrease by Does Paxil treat hot flashes associated with menopause. Low Dose Paroxetine for the Treatment of Hot Flashes Paroxetine Paxil NAMI National Alliance on Mental Illness Hot flashes —whether. SSRIs and SNRIs are thought to work by modifying the amounts of certain brain chemicals. Don't use paroxetine if you are. does sertraline make you tired Jul 12, 2014. If you are taking either of these, how well did it work for you? How long before you saw reduction in your flashes? I just started on Brisdelle. Answers - Posted in paroxetine, side effect. I suppose they might work to decrease anxiety. How long does it take to start working?