Kinetics of chloroquine

Discussion in 'Plaquenil Generic' started by Amon Mur, 08-Mar-2020.

  1. Gizzatulin User

    Kinetics of chloroquine


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

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    Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. It is also being used as an experimental treatment for SARS-CoV-2. Taken together, genetic data suggest that chloroquine resistance is a complex phenotype, resulting from at least two functionally independent events changes in the chloroquine import kinetics and the acquisition of a chloroquine efflux mechanism. The distribution of chloroquine was studied in the tissues and blood of rat. 2. 2. The time to peak concentration and the maximum concentration varied in various tissues and were higher than for plasma and red blood cells.

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Kinetics of chloroquine

    Kinetics of Chloroquine Uptake into Isolated Rat Hepatocytes., Identification of a Chloroquine Importer in Plasmodium falciparum

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  5. Hydroxychloroquine HCQ and chloroquine CQ are well absorbed 0.7-0.8 bioavailability when given orally. Severe malnutrition such as kwashiorkor effects absorption but diahrrea does not. Both.

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    Plasma concentrations of chloroquine and the principal metabolite desethylchloroquine, electrocardiograph intervals, and arterial blood pressure were measured at frequent intervals to determine the relationship between cardiovascular effects and plasma concentrations. Peak plasma concentrations ranged between 7 mean 2913 ng ml‐1. Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Pharmacokinetics of hydroxychloroquine and chloroquine during treatment of rheumatic diseases. Furst DE1. Author information 1Arthritis Clinic Research Unit, Virginia, Mason Arthritis Clinic Research, Seattle, WA 98101, USA. Hydroxychloroquine HCQ and chloroquine CQ are well absorbed 0.7-0.8 bioavailability when given orally.

     
  6. AlexFree User

    If you are new to hearing about the dangers of the Fluoroquinolone drugs, then this introduction is for you. FDA updates warnings for oral and injectable fluoroquinolone Hydroxychloroquine Plaquenil Toxicity and Recommendations. Hydroxychloroquine Plaquenil Side Effects & Dosage for.
     
  7. MC2007 XenForo Moderator

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Plaquenil and Aspirin drug interactions - eHealthMe Plaquenil hydroxychloroquine sulfate dose, indications. Aspirin, hydroxychloroquine, and hepatic enzyme abnormalities.
     
  8. Kastorskiy Moderator

    Buying Chloroquine in the USA Americas - United States. Chloroquine requires a prescription in the US. You will need to find a clinic of some sort. If you can tell me what cities you will be in, I'll see if I can find some less expensive options for getting the prescription. Chloroquine is widely available over the counter in much of Central America as cloroquina or Aralen.

    Where To Buy Chloroquine Phosphate