How does chloroquine work at the cellular level

Discussion in 'Pharmacy Northwest Canada' started by nikonlay, 22-Feb-2020.

  1. mubsbloro XenForo Moderator

    How does chloroquine work at the cellular level


    It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc.

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    Chloroquine binds to heme or FP to form what is known as the FP-Chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-Chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. In essence, the parasite cell drowns in its own metabolic products. Chloroquine may increase cyclosporine blood levels. Cyclosporine blood levels should be monitored and, if necessary, chloroquine should be stopped. Combining chloroquine and mefloquine may increase the risk of seizures. Chloroquine can reduce the antibody response to primary immunization with intradermal human diploid-cell rabies vaccine. Summary. Chloroquine is an anti-malarial drug available at pharmacies for people traveling to area with malaria risks. Note based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested.

    The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea.

    How does chloroquine work at the cellular level

    Inhibition of autophagy with bafilomycin and chloroquine., Aralen chloroquine Malaria Drug Side Effects & Dosage

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  6. It would be an additional effect as well as this would not play a role in cell culture. My guess for the pneumonia is the cytokine induction induced by viral RNA or other innate immune signals. Another option is induced cell death by virus infection. There might be a source for coronavirus-induced cell death out there.

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    Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. At the cellular level, several direct and indirect mechanisms have been described that account for the immunomodulatory effects of hydroxychloroquine and chloroquine. It is a hydroxylated version of chloroquine, with a similar mechanism of action. However, following an identical dose of hydroxychloroquine and chloroquine, tissue levels of chloroquine are 2.5 times those of hydroxychloroquine. Hydroxychloroquine is preferred due to its safer profile.

     
  7. osada XenForo Moderator

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Hydroxychloroquine Plaquenil Side Effects & Dosage for. Plaquenil Oral Uses, Side Effects, Interactions, Pictures. Coronavirus and Arthritis What You Need to Know.
     
  8. Gricha Well-Known Member

    Download PDF Many systemic medications may cause retinal toxicity. Hydroxychloroquine-Induced Retinal Toxicity - American. Correct diagnosis for a Plaquenil exam - American Academy. Hydroxychloroquine Plaquenil Toxicity and Recommendations.
     
  9. VaSiLek Well-Known Member

    Aralen Chloroquine Uses, Dosage, Side Effects. Apr 02, 2019 Chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract, and only a small proportion of the administered dose is found in the stools. Approximately 55% of the drug in the plasma is bound to nondiffusible plasma constituents. Excretion of chloroquine is quite slow, but is increased by acidification of the urine.

    Chloroquine Article about Chloroquine by The Free Dictionary
     
  10. cg cccp Guest

    Hydroxychloroquine Side-effects, uses, time to work It may be 12 weeks or longer before you notice any benefit. Because it's a long-term treatment it's important to keep taking hydroxychloroquine unless you have severe side-effects even if it doesn't seem to be working at first even when your symptoms improve to help keep the disease under control.

    Plaquenil.long do I have to wait? DailyStrength