Pharmacokinetics of chloroquine phosphate

Discussion in 'Hydroxychloroquine Sulfate 200 Mg' started by Knup, 23-Feb-2020.

  1. MrKroll User

    Pharmacokinetics of chloroquine phosphate


    There is increased plasma protein binding, predominantly to α=8 hours) are prolonged by 50%. Systemic clearance is predominantly by hepatic biotransformation to more polar metabolites (quinine 80%, quinidine 65%) and the remaining drug is eliminated unchanged by the kidney.

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    How to use Chloroquine Phosphate. Take this medication by mouth, usually with food to prevent stomach upset, exactly as directed by your doctor. Daily or weekly dosing, dosage amount, and length. This paper presents the current state of knowledge on chloroquine disposition, with special emphasis on stereoselectivity and microsomal metabolism. In addition, the impact of the patient’s physiopathological status and ethnic origin on chloroquine pharmacokinetics is discussed. In humans, chloroquine concentrations decline multiexponentially. Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum.

    Quinine and chloroquine may cause potentially lethal hypotension if given by intravenous injection. Quinine is well absorbed by mouth or following intramuscular injection even in severe cases of malaria (estimated bioavailability more than 85%).

    Pharmacokinetics of chloroquine phosphate

    Chloroquine - Wikipedia, Clinical Pharmacokinetics and Metabolism of Chloroquine.

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  6. Medscape - Indication-specific dosing for Aralen, Chloroquine phosphate chloroquine, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.

    • Aralen, Chloroquine phosphate chloroquine dosing, indications..
    • Chloroquine phosphate C18H32ClN3O8P2 - PubChem.
    • Pharmacokinetics of Quinine, Chloroquine and Amodiaquine SpringerLink.

    Hydroxychloroquine HCQ and chloroquine CQ are well absorbed 0.7-0.8 bioavailability when given orally. Severe malnutrition such as kwashiorkor effects absorption but diahrrea does not. Both HCQ and CQ have prolonged half-lives, between 40 and 50 days, and low blood clearance e.g. hydroxychloroquine's blood clearance is 96 ml/min. The N-dealkylated metabolites of chloroquine are of pharmacological and toxicological importance. It may, therefore, be necessary to monitor their plasma concentrations in addition to that of chloroquine in patients on long-term chloroquine therapy. Continue reading full article Irreversible retinal damage observed in some patients; significant risk factors for retinal damage include daily doses of chloroquine phosphate 2.3 mg/kg of actual body weight, durations of use greater than five years, subnormal glomerular filtration, use of some concomitant drug products such as tamoxifen citrate, and concurrent macular disease.

     
  7. voron User

    Download PDF Drug-induced ocular side effects are back in the spotlight, thanks to the Academy’s revision of its recommendations on screening for retinal toxicity from chloroquine and its analogue hydroxychloroquine (Plaquenil). The Risk of Retinal Toxicity with Plaquenil - Sjogren's Protecting your eyesight when taking Plaquenil Lupus. Plaquenil Side Effects Common, Severe, Long Term -
     
  8. Kila User

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Plaquenil Withdrawal? What is the correct way to discontinue use of plaquenil? Let me tell you what weaning down from Plaquenil is like.
     
  9. Nataliyfda XenForo Moderator

    Plaquenil Hydroxychloroquine Sulfate - Sanofi PrPLAQUENIL® Hydroxychloroquine Sulfate Tablets USP 200 mg ACTIONS AND CLINICAL PHARMACOLOGY PLAQUENIL hydroxychloroquine sulfate tablets belongs to the 4-aminoquinoline class. PLAQUENIL has been beneficial for patients with rheumatoid arthritis and lupus erythematosus, especially chronic discoid lupus.

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  10. KatjaK Guest

    PLAQUENIL - Hydroxychloroquine - Posologie, Effets. Mg/kg et par jour pendant une durée minimale de 6 mois. Lupus érythémateux discoïde ou subaigu Initialement 1 à 2 comprimés par jour 200 à 400 mg/jour jusqu'à disparition des lésions, pouvant être augmentée à 3 comprimés 600 mg par jour, en cas de non-réponse après 1 à 2 mois.

    Hydroxychloroquine Oral Tablet 200Mg Drug Medication Dosage Information