In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Plaquenil hair Hydroxychloroquine pill identification 347 Despite its common use, retinal toxicity from hydroxychloroquine has a low incidence 1. However, retinal toxicity can have a devastating effect on vision, and even after cessation of this drug there may be little visual recovery and even progressive visual loss 2. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes. Retinal toxicity associated with chronic exposure to hydroxychloroquine and its ocular screening. Review. Kidney or liver disorders can decrease the effective rate of drug removal which in effect increases the blood level because the clearance of hydroxychloroquine is made by both the kidney and the liver. The mechanism of. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Does hydroxychloroquine have renal toxicity Drug spotlight on hydroxychloroquine Lupus Foundation of., Plaquenil Hydroxychloroquine - Side Effects, Dosage. Does plaquenil cause melasma Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine -sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. Hydroxychloroquine - Wikipedia. Retinal toxicity associated with chronic exposure to.. Hydroxychloroquine Use and Risk of CKD in Patients with.. Hydroxychloroquine is a well tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity. Within the eye, hydroxychloroquine negatively impacts the cornea, ciliary body, and retina. Both chloroquine and hydroxychloroquine have excellent oral absorption and bioavailability. Both have a long and variable plasma elimination half-life because of a high volume of distribution, an extended mean residence time HCQ 1300 hours and CQ 900 hours and with about half the drug metabolites undergoing unmodified renal clearance. However, children are more sensitive to the effects of this medicine than adults. Safety and efficacy of hydroxychloroquine to treat lupus and arthritis have not been established in children.