According to legend it was first brought to Europe by a Countess who had been treated with it in Peru in the 1600s. In 1820, two French chemists isolated quinine from the cinchona bark and quinine became a treatment of reference for intermittent fever throughout the world. Quinine remains an important and effective treatment for malaria today, despite sporadic observations of quinine resistance. Chloroquine falciparum target Chloroquine synthesis mechanism Treatment of P. vivax infections. P. vivax infections should be treated with an ACT or chloroquine in areas without chloroquine-resistant P. areas where chloroquine-resistant P. vivax has been identified, infections should be treated with an ACT, preferably one in which the partner medicine has a long half-life. Apr 22, 2009 The history of anti-malarial medicine has been marked by a constant struggle between evolving drug-resistant parasites and the search for new drugs. Chloroquine, an anti-malarial drug, was the. Topics under Malaria. Malaria Prevention 23 drugs Alternative treatments for Malaria. The following products are considered to be alternative treatments or natural remedies for Malaria. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. These compounds belonged to a new class of antimalarials, the four-amino quinolines. Research by German scientists to discover a substitute for quinine led to the synthesis in 1934 of Resochin (chloroquine) and Sontochin (3-methyl-chloroquine). Anti-malarial medicine for chloroquine resistant malaira History of antimalarials Medicines for Malaria Venture, A to Z of malaria - Is chloroquine phosphate malaria medicationHydroxychloroquine sulphate indications Current status of drug-resistant malaria 10 3. Causes of resistance 12 3.1 Definition of antimalarial drug resistance 12 3.2 Malaria treatment failure 12 3.3 Mechanisms of antimalarial resistance 12 3.3.1 Chloroquine resistance 12 3.3.2 Antifolate combination drugs 13 3.3.3 Atovaquone 13 3.4 Factors contributing to the spread of resistance 13 Drug resistance in malaria. List of Malaria Medications 31 Compared -. Antimalarial Drug revives the hope to treat Coronavirus infection.. Aralen chloroquine is an antimalarial drug used for the treatment of malaria and extraintestinal amebiasis. Common side effects are reduced hearing, tinnitus, nausea, vomiting, and diarrhea. Dosage, drug interactions, and pregnancy and breastfeeding safety are provided. Find patient medical information for Malarone Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Other Drugs with Antimalarial Activity Many drugs have been tested for their potential anti malarial effects. Research into newer anti malarials being scanty, such attempts might throw up one or two candidates for use in malaria, however, these drugs are yet to find a place in standard anti malarial regimen.