Studies have shown that atovaquone and proguanil hydrochloride is safe and effective for prevention of falciparum malaria in lifelong residents of malaria-endemic countries, but little is known about non-immune travellers. In a double-blind equivalence trial, 1083 participants travelling to a malaria-endemic area were randomly assigned to two treatment groups: atovaquone-proguanil plus placebos for chloroquine and proguanil, or chloroquine, proguanil, and placebo for atovaquone-proguanil. Natural substitute for chloroquine Chloroquine lysosome OverviewMedical usesAdverse effectsOverdoseResistance in malaria Oct 01, 2001 Sixty-four subjects in the atovaquone-proguanil group and 76 subjects in the mefloquine group discontinued use of the study drug prematurely. The reasons for premature discontinuation in the atovaquone-proguanil group versus the mefloquine group were AEs 16 subjects vs. 26 subjects, protocol violation 8 vs. 10, and other 40 vs. 40. Atovaquone/proguanil, sold under the trade names Malarone among others, is a combination of two antimalarial medication atovaquone and proguanil. It is used to treat and prevent malaria, including chloroquine -resistant malaria. It is not recommended for severe or complicated malaria. It is taken by mouth. Serum samples were tested for antibodies to a malaria circumsporozoite protein. Follow-up was by telephone 7 and 60 days after travel and at a clinic at 28 days. Chloroquine vs atovaquone Atovaquone-Proguanil versus Chloroquine-Proguanil for., Atovaquone-Proguanil versus Mefloquine for Malaria. Plaquenil insomnia Oct 09, 2018 This is why we often refer to the combination of Atovaquone/Proguanil as Generic Malarone – same ingredients, no brand name. Malarone vs Atovquone/Proguanil Which Should I Choose? It’s really up to you. Some people prefer to use Malarone as they’ve used it before and it works for them. Others prefer Atovaquone/Proguanil as it is more. Malarone vs Atovquone/Proguanil Whats the Difference? Nomad. Atovaquone/proguanil - Wikipedia. DailyMed - MALARONE- atovaquone and proguanil hydrochloride.. Chloroquine has side effects, but is the recommended drug for the nature of mosquito/nature of malaria in the DR. Malarone works for other malarias my friend who spent 2 months in Kenya took it. Rather like the flu shot which treats only certain strains and not all. Chloroquine can also be used to treat malaria after you get it. Kaki Malarone is the brand name Atovaquone 250 mg & Proguanil 100mg are the active ingredients and while I might wonder about the ingredients in made in China generics any generic made in a developed country should be fine and yes you really do just pay more for the brand name. This medication contains 2 medicines atovaquone and proguanil. It is used to prevent and treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver.