Chloroquine action

Discussion in 'Hydroxychloroquine 200mg' started by honinvoth, 28-Feb-2020.

  1. DafDiallhah Well-Known Member

    Chloroquine action


    Inhibition of protein synthesis is also observed, evidently as a secondary effect. Inhibition of DNA replication is proposed as a general mechanism of the antimicrobial action of chloroquine.

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    Chloroquine is the drug of choice for travel to areas where chloroquine resistance has not been described. Chloroquine is active against the erythrocytic forms Fig. 6.3 of sensitive strains of all species of malaria, and it is also gametocidal against P. vivax, P. malariae, and P. ovale. Of note, chloroquine and hydroxychloroquine are considered to be safe and side-effects are generally mild and transitory. However, the margin between the therapeutic and toxic dose is narrow and chloroquine poisoning has been associated with cardiovascular disorders that can be life-threatening Frisk-Holmberg et al. 1983. Chloroquine and. Several lysosomal inhibitors such as bafilomycin A1 BafA1, protease inhibitors and chloroquine CQ, have been used interchangeably to block autophagy in in vitro experiments assuming that they all primarily block lysosomal degradation.

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    Chloroquine action

    Chloroquine & Hydroxychloroquine supporting chemo., Of chloroquine and COVID-19 - ScienceDirect

  2. Hydroxychloroquine 400 mg od
  3. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in.

    • Chloroquine Oral Uses, Side Effects, Interactions..
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    • Chloroquine Indications, Side Effects, Warnings -.

    Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA. Aralen chloroquine is an antimalarial drug used for the treatment of malaria and extraintestinal amebiasis. Common side effects are reduced hearing, tinnitus, nausea, vomiting, and diarrhea. Dosage, drug interactions, and pregnancy and breastfeeding safety are provided. Chloroquine binds to heme or FP to form what is known as the FP-Chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-Chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. In essence, the parasite cell drowns in its own metabolic products.

     
  4. Nepeyka Well-Known Member

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Plaquenil Uses, Dosage & Side Effects - Plaquenil Hydroxychloroquine Side effects, Images, Uses. Common and Rare Side Effects for Cephalexin Oral
     
  5. eduardus Well-Known Member

    Plaquenil Hydroxychloroquine - Side Effects, Dosage. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others.

    Plaquenil hydroxychloroquine sulfate dosing, indications.