One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Plaquenil and teeth loss Teva hydroxychloroquine Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy. Hydroxychloroquine Toxicity Screening Is Key. Hydroxychloroquine Plaquenil is a disease-modifying antirheumatic drug that is commonly used to reduce arthritic pain and swelling. Signs and symptoms. “The association of Plaquenil therapy with macular toxicity is well established,” said Michael F. Marmor, MD, at the Byers Eye Institute at Stanford University. Monitor patients for cardiomyopathy during PLAQUENIL therapy. Chronic toxicity should be considered when conduction disorders bundle branch block/atrio-ventricular heart block or biventricular. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil renal toxicity Hydroxychloroquine toxicity - EyeWiki, Drug Toxicity to the Retina and Optic Nerve Are You Missing. New guidelines for plaquenil macuopathyPlaquenil skin reactionChloroquine dose india The patient was diagnosed with retinal toxicity secondary to hydroxychloroquine probably potentiated by renal impairment. Risk factors for retinal toxicity secondary to hydroxychloroquine can be broadly divided into dose-related and patient-related factors. A Case of Severe Hydroxychloroquine-Induced Retinal Toxicity.. PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION. Drug Toxicity to the Retina and Optic Nerve Are You.. Aug 26, 2016 Lupus is an autoimmune disease that can affect almost any part of your body, most often your joints, skin, kidneys, heart, lungs, blood, or brain. Your two kidneys are part of your renal system, which also includes two ureters, the bladder, and the urethra. As the primary organs of the renal system, your kidneys are responsible for Renal ischemia/reperfusion I/R injury, the major cause of acute kidney injury AKI, is associated with severe morbidity and mortality in both developing and developed countries. Accumulating evidence has suggested that inflammation plays a critical role in the pathology of ischemic injury. Sep 15, 2014 Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy.