Malaria resistance to chloroquine

Discussion in 'Chloroquine' started by rwety, 16-Mar-2020.

  1. dkozh Moderator

    Malaria resistance to chloroquine


    Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

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    Chloroquine, an anti-malaria drug that President Trump fast-tracked for clinical testing this week in the fight against coronavirus, can be deadly for kids, according to an Oklahoma family who said Chloroquine-resistant malaria is exactly what it sounds like—particular types of malaria which are not cured by treatment with chloroquine. Chloroquine was first discovered in the 1930s in Germany and began to be widely used as an anti-malaria post-World War II, in the late 1940s. The development of resistance to drugs poses one of the greatest threats to malaria control and results in increased malaria morbidity and mortality. Resistance to currently available antimalarial drugs has been confirmed in only two of the four human malaria parasite species, Plasmodium falciparum and P. vivax.

    Chloroquine is also used to treat amebiasis (infection caused by amoebae). Chloroquine is used to treat and to prevent malaria.

    Malaria resistance to chloroquine

    Chloroquine - FDA prescribing information, side effects., Chloroquine Resistant Malaria

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  4. Malaria Information and Prophylaxis by Country; Country Areas with Malaria Drug Resistance 2 Malaria Species 3 Recommended Chemoprophylaxis 4 Key Information Needed and Helpful Links to Assess Need for Prophylaxis for Select Countries; Democratic Republic of the Congo Congo-Kinshasa All Chloroquine P. falciparum 90%, P. ovale 5%, P. vivax rare

    • CDC - Malaria - Travelers - Malaria Information and..
    • CDC - Malaria - Malaria Worldwide - How Can Malaria Cases..
    • Malaria understanding drug resistance - BugBitten.

    Despite its strategic location and importance, malaria epidemiology and molecular status of chloroquine resistance had not been well documented, and since chloroquine CQ, as the first-line treatment in Plasmodium falciparum infection was discontinued since 2008, it was expected that CQ-sensitive haplotype would be more abundant. This deficiency explains the reduced ability of chloroquine-resistant parasites to concentrate chloroquine, and it suggests that chloroquine resistance is due to a decrease in the number, affinity, or accessibility of chloroquine receptor sites on a constituent of the malaria parasite. But just when malaria appeared to be well on its way to eradication, this parasitic protozoan mutated in ways that has enabled it to resist frontline antimalarial drugs. This resistance is a major reason that malaria, one of the world’s oldest diseases, still claims the lives of about 400,000 people each year 1.

     
  5. Garbage New Member

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine MedlinePlus Drug Information CHLOROQUINE PHOSPHATE TABLET, USP Chloroquine - Wikipedia
     
  6. autorun XenForo Moderator

    Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Pharmacokinetic Interactions between Primaquine and. Malaria Causes, Symptoms, Treatment, & Prevention. Methods and Applications of Antimalarial Assays.
     
  7. Solmyr Moderator

    What can Hydroxychloroquine Plaquenil do to my eyes? The actual incidence of retinal toxicity from hydroxychloroquine is difficult to pin down because there is usually a long time between being started on the drug and the start of any identifiable retinal toxicity. The overall rate of probable retinal toxicity is in the range of 1 of every 200 people treated.

    This is Why You Need Multifocal ERG if You Have Plaquenil.
     
  8. r2d2 XenForo Moderator

    Hydroxychloroquine - Wikipedia Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda.

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