Signs and symptoms of lupus may vary over time and overlap with those of many other disorders. The combination of blood and urine tests, signs and symptoms, and physical examination findings leads to the diagnosis. Lupus can harm your kidneys in many different ways, and treatments can vary, depending on the type of damage that occurs. Plaquenil neuropathy What is hydroxychloroquine sulfate used for For the treatment of systemic lupus erythematosus, patients should take 200 mg to 400 mg of hydroxychloroquine per day as one dose or divided into two separate doses. 1, 2 The recommended hydroxychloroquine dosage for rheumatoid arthritis is 400 mg to 600 mg a day by mouth as a single dose or divided into two separate doses. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis or juvenile idiopathic arthritis and other autoimmune diseases. It is not clear why hydroxychloroquine is effective at treating autoimmune diseases. Hydroxychloroquine is generally the first line of treatment for someone who has been diagnosed with lupus. It is used for skin and joint involvement, muscle inflammation, fever, fatigue, pleurisy, to reduce the development of renal kidney disease and chronic damage, and for its steroid-sparing properties. The sample can be obtained with a needle or through a small incision. In some cases, it's necessary to test a small sample of kidney tissue to determine what the best treatment might be. Lupus treatment hydroxychloroquine Lupus Symptoms, Diagnosis and Treatments, Hydroxychloroquine Plaquenil Can plaquenil cause numbness in tailbone area and legs Originally, hydroxychloroquine was used to prevent and treat malaria and was considered very effective. Now it is generally used for rheumatoid arthritis, but it has also been shown to work well for juvenile arthritis, some lupus symptoms, and other types of autoimmune conditions. RA and Hydroxychloroquine How Effective is it for Rheumatoid.. Hydroxychloroquine Prescriptions - LUPUS UK. How is plaquenil hydroxychloroquine used to treat lupus?. Plaquenil is most known for its original purpose treating and preventing malaria. Malaria is a disease caused by parasites that can enter the body through a mosquito bite. The essential ingredient, known as quinine, is derived from the bark of the cinchona plant. Potential side effects of anti-malarial drugs include Skin rashes and pigment change. Atabrine, specifically, can cause yellow pigmentation of skin. Sometimes Plaquenil can also deposit in the tissues. Dry skin. Loss of appetite. Abdominal bloating. Upset stomach. Stomach cramps. Retinal damage. Hydroxychloroquine oral tablet is available as a brand-name drug and a generic drug. Brand name Plaquenil. Hydroxychloroquine comes only as a tablet you take by mouth. Hydroxychloroquine is used to treat malaria, lupus erythematosus, and rheumatoid arthritis.