Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Autophagy inhibitors hydroxychloroquine Prophylaxis for international travel to chloroquine resistant area Chloroquine phosphate tablets 500mg Hydroxychloroquine sulfate tablets usp 200 mg Does anyone else feel worse on Plaquenil? Support Forums Rheumatoid Arthritis New Topic Reply. Made me feel out of it all the time, sort of dizzy and ou of balance. I had to go off it after 6 weeks. They put me on methotrexate and that worked much better. Goodluck, golitho I started plaquenil 1.5 weeks ago, on the day my period started, so I haven't been on it for that long. I was just noticing, however, that I am NOT experiencing the intense ovulation cramps that have been plaguing me for a while I feel a teensie amt of discomfort, instead. Hydroxychloroquine is commonly used alongside other disease-modifying drugs including methotrexate – especially for rheumatoid arthritis. However, some drugs can interact with hydroxychloroquine. Indigestion remedies for example, antacids including some over-the-counter preparations can stop hydroxychloroquine being absorbed. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Hydroxychloroquine makes me feel worse Is extreme fatigue a side effect of Plaquenil?, Irritability and increased hot flashes with Plaquenil How can plaquenil affect your eyesThe deneric plaquenil is not as good as non genericHydroxy chloroquine oral or sulfate Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America. Hydroxychloroquine - Side Effects, Dosage, Interactions.. Hydroxychloroquine Side-effects, uses, time to work. Plaquenil, anxiety and dizziness. Dont know what to do. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Went like this back and forth and it was definitely the medicine. Also I started to feel worse while taking it. It could be that the weather is getting colder and that always makes me feel worse. but we decided I couldn't tolerate an increase in dosage which was what would have been next on the treatment plan so we moved on to something else. Methylfolate Makes Depression Worse For Me – Now What? Don’t worry – you have a couple of options. If you’re sure this isn’t just your body adjusting to methylfolate the symptoms last beyond the first week of moderate supplementation then it’s time to check to see if you fit the profile of an undermethylator. If that sounds like.