Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Months for hydroxychloroquine to work on joints Hydroxychloroquine and chloroquin When I was first diagnosed with lupus I was put on prednisone and plaquenil to help control my severe joint inflammation. The prednisone began workiing in 3 days and helped reduce my joint inflammation. I had some issues with the plaquenil, nausea and extremity swelling. Our Plaquenil hydroxychloroquine Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Three anti-malarial drugs are prescribed for lupus symptoms. Hydroxychloroquine Plaquenil is the most commonly prescribed because it is generally believed to cause fewer side effects; chloroquine Aralen has a reputation for more serious side effects, but it may be prescribed in situations where hydroxychloroquine cannot be used. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Plaquenil and prednisone side effects Plaquenil and Prednisone, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Hydroxychloroquine 200 mg tab en espanolPlaquenil contraindicationsCan i take plaquenil with hydroxyzineHydroxychloroquine eye symptoms Common side effects Nausea and diarrhea This can often can be combatted by taking Plaquenil with food or milk. Dizziness Precautions with this side effect Do not drive, use machinery. Cramps. Headache. Dry skin. Loss of appetite. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Treating Lupus with Anti-Malarial Drugs Johns Hopkins.. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. I have been on prednisone for 15 months and am down to 5 mg. I cannot seem to get below that dose without having a flate. My rheumatologist has started me on Plaquenil and has said this should help me get off the prednisone. He said he would rather see me on Plaquenil instead of prednisone due to less side effects of the Plaquenil. But you can’t even compare it to the only other things I have to treat lupus—prednisone, where 100 percent of people get side effects, or immunosuppressive drugs, which suppress the immune system, potentially causing infections, low blood counts, and liver toxicity. It is created by eHealthMe based on reports of 13,785 people who have side effects when taking Prednisone and Plaquenil from Food and Drug Administration FDA, and is updated regularly. On eHealthMe, you can evaluate side effects and drug interactions from 16 million FDA reports.