In some cases, they may not be available in all strengths or forms as the brand-name drug. Sulfasalazine is used to reduce inflammation and pain in rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), and ulcerative colitis (UC). Methotrexate trexall and hydroxychloroquine plaquenil Plaquenil for autoimmune hepatitis Methotrexate Sulphasalazine Hydroxychloroquine ABSOLUTE CONTRAINDICATION. or sulfasalazine. with patients commonly taking two or Original Article from The New England Journal of Medicine — Treatment of Rheumatoid Arthritis with Methotrexate Alone, Sulfasalazine and Hydroxychloroquine, or a Combination of All Three Medications Hydroxychloroquine comes in an oral tablet. Adult dosing ranges from 200 mg or 400 mg per day 6.5mg/kg. In some cases, higher doses can be used. It is recommended one tablet twice daily if taking more than one tablet. It is recommended to be taken with food. It’s used to decrease pain and swelling in the joints. In RA and JRA, the medication is used to treat people who haven’t responded to other therapies. Sulfasalazine taken with hydroxychloroquine Sulfasalazine for Rheumatoid Arthritis, Treatment of Rheumatoid Arthritis with Methotrexate Alone. Retinal toxicity and plaquenilSide effects of chloroquine Patients should drink a lot of fluids ought to avoid taking it on an empty stomach or with antacids and while taking sulfasalazine. Hydroxychloroquine — Hydroxychloroquine, initially created as a treatment for malaria, was afterwards discovered to enhance outward indications of arthritis. DMARDs Disease-modifying antirheumatic drugs Side Effects. Hydroxychloroquine Plaquenil. Sulfasalazine and Plaquenil drug interactions - eHealthMe. Jul 25, 2015 I've never taken sulphasalazine but have been on a combination of hydroxychloroquine and methotrexate for years. Hydroxy is one of the mildest DMARDS but seems to work well in combination with others. Take hydroxychloroquine with a meal or a glass of milk. To prevent malaria Start taking the medicine 2 weeks before entering an area where malaria is common. Continue taking the medicine. Hydroxychloroquine is sometimes combined with methotrexate for additive benefits for signs and symptoms or as part of a regimen of “triple therapy” with methotrexate and sulfasalazine. Mechanism The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is unknown but is thought to involve changes in antigen presentation or effects on the innate immune system.