Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Discontinuing plaquenil now have muscle spasms Plaquenil for itp 1 80 Thus, for subjects who are of short stature, daily doses must be calculated on the basis of ideal body weight. Kidney or liver disorders can decrease the effective rate of drug removal which in effect increases the blood level because the clearance of hydroxychloroquine is made by both the kidney and the liver. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a ppatient’s real body weight. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil toxicity ideal body weight Ask the Expert Plaquenil and Sjögren’s, Plaquenil Risk Calculators Do i need prescription for chloroquine phosphateDoes plaquenil cause eye problemsCan i take plaquenil and adipex togetherHydroxychloroquine eye damage Daily dosage exceeding 6.5 mg/kg ideal body weight. Absolute body weight used as a guide to dosage, could result in an overdosage in the obese; renal insufficiency; cumulative dose more than 200 g; elderly; impaired visual acuity. DailyMed - PLAQUENIL- hydroxychloroquine sulfate tablet. Plaquenil Side Effects Common, Severe, Long Term -. Hydroxychloroquine Plaquenil Dosing Calculator - MDCalc. The most recent 2016 guidelines from the American Academy of Ophthalmology AAO recommend the dose of HCQ ≤5 mg/kg real body weight to minimize toxicity 1. According to these new guidelines, the risk of HCQ retinal toxicity is less than 1 % in the first year of therapy and less than 2 % up to 10 years of therapy. The AAO published dosing and screening recommendations for chloroquine and hydroxychloroquine in 2016, revising previous recommendations published in 2011. The current maximum daily HCQ dose recommended by the AAO is 5 mg/kg of real weight. The 2011 guidelines suggested a maximum dose of 6.5 mg/kg of ideal weight. Aug 30, 2011 A daily dose of 6.5mg/kg ideal body weight places patients at higher risk, but a daily dose below this level did not preclude the patient from developing toxicity after many years of treatment. A cumulative dose of 1000g of hydroxychloroquine or 460g of chloroquine was likely the largest risk factor, which was typically achieved after 5-7 years of a typical dosage 8, 10.