I am not shocked about having it just being diagnosed with it. I have seen my rheumatologist for five years and I guess she just thought it was time. Plaquenil and surgery risk Stopping plaquenil cold turkey Low body fat and increase risk for chloroquine toxicity Aug 01, 2009 Lucy, meds effect us all differently. Almost any med that can cause weight loss can also cause weight gain. I also find that eating a lot of carbohydrates helps with the GI effects of the plaq and that can contribute to weight gain. I was on Plaquenil for 2 yrs and gained 60 pounds. Hence, if the loss of appetite and weight loss started after you started on this drug, then yes, it could be due to Plaquenil. However, if you had loss of appetite and weight loss before your started this drug, then the drug can aggravate the process. In this case, the cause of loss f appetite and weight loss has to be found. Plaquenil and Weight loss - from FDA reports Summary Weight loss is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years, also take medication Enbrel, and have Pain. She tried to put me on it two years ago even before she diagnosed me because she has always suspected lupus. Anyway, I'm scared to death to take plaquenil but I know that I probably should. Does plaquenil cause weight loss or weight gain Plaquenil Side Effects Common, Severe, Long Term -, Plaquenil and loss of appetite - Lupus - MedHelp Chloroquine dose in vivax malariaPlaquenil dose for discoid lupusIs plaquenil a corticosteroidCheap aralen medication GOOD NEWS hair loss & weight gain are NOT associated with Plaquenil. The other two classes are steroids & immunosuppressants, used where major organs are compromised. These types have a huge range of possible side effects---which is possibly what you were thinking of when you cited weight gain & hair loss. Want to know good stuff about plaquenil - HealthBoards. Will you have Weight loss with Plaquenil - eHealthMe. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking Plaquenil and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Loss of appetite, weight loss; mood changes, feeling nervous or irritable; skin rash or itching; or; hair loss. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Lynwood, I can't answer your question about weight gain or loss on plaquenil but I did go off plaquenil a few months ago and haven't been the same since. I regret the decision which had I made because I'd felt pretty well for quite some time and was doing my best to slowly get off as many meds as possible.