One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Best price for plaquenil Chloroquine cq Rheumatoid drug plaquenil Abstract. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Ideal body weight Plaquenil dosing calculations are reprinted with permission from The Lupus Encyclopedia A Comprehensive Guide for Patients and Families, by Donald E. Thomas, published by Johns Hopkins University Press. Standard dosing At first, 800 milligrams mg 4 tablets taken as a single dose. Then, 400 mg taken 6 hours, 24 hours, and 48 hours after the first dose. Weight-based dosing Dose is based on body weight and must be determined by your doctor. At first, 13 milligram mg per kilogram kg of body weight taken as a single dose. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Hydroxychloroquine dosage calculator New Guidelines on Hydroxychloroquine Dosage - Where Are We., Protecting your eyesight when taking Plaquenil Lupus. Mferg plaquenilWhat does chloroquine do to dnaPlaquenil hyperpigmentation histologyChloroquine action This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day 200 bid. The calculator below can be used to calculate a patient’s cumulative dose based on their dosage and duration of use. For dosages that have changed over time additional rows can be added to the calculation by pressing the “+” button. Plaquenil Risk Calculators. Hydroxychloroquine Oral Route Proper Use - Mayo Clinic. Despite Plaquenil dosing recommendations, retinal toxicity.. Medication Dosage. Several factors have been associated with the risk of developing hydroxychloroquine retinopathy. One of the most important appears to be dosage—with debate over whether daily intake vs. cumulative dosage is most significant. Prescribing providers may not routinely calculate the optimal dose of hydroxychloroquine due to a number of factors, including 1 toxicity is a cumulative effect and takes years to develop; 2 the calculations are cumbersome and time during a clinical encounter is short; 3 lack of familiarity with recommended dosing guidelines; and 4. Ideal Body Weight for Calculating Hydroxychloroquine Dosage. The most important risk factor for hydroxychloroquine retinopathy is the daily dose of the drug. If a patient is overweight, one should use the ideal body weight to assess whether the doaily dose is in the toxic range /= 6.5 mg/kg/day.