Moreover, it is used as an adjunct in chemotherapy, and it is being investigated as a treatment for diabetes and heart disease, thanks to its anti-inflammatory, lipid-lowering, and antithrombotic properties. But as ophthalmologists know, excessive HCQ dosages can result in toxic damage to the eye. Hydroxychloroquine diarea How long do plaquenil stay in your system How much does aralen cost Chloroquine and Hydroxychloroquine. Chloroquine and its derivative, hydroxychloroquine sulfate, which have been useful in treating malaria and in larger doses, collagen-vascular disease, cause a cumulative dose-related pigmentary retinopathy. Because the most commonly prescribed dose of hydroxychloroquine is 400 mg/day, women are on average overdosed much more often than men are based on IBW or RBW, and HR is almost exclusively a problem of women. In this article, we present evidence that the 20 AAO guidelines warnings are valid. Irreversible retinal damage observed in some patients who had received hydroxychloroquine sulfate; significant risk factors for retinal damage include daily doses of hydroxychloroquine sulfate greater than 6.5 mg/kg 5 mg/kg base of actual body weight, durations of use greater than five years, subnormal glomerular filtration. Highlights of the 2016 guidelines include the following. “The bottom line is that the daily dose should be 5.0 mg per kg or less, using real body weight,” said Michael F. In an effort to reduce the incidence of HCQ retinopathy, the Academy published screening guidelines in 2002. Here’s an overview of the latest guidelines—and troubling evidence that far too many patients are still receiving too high a dose of HCQ (see “Excessive Dosing Still a Problem,” below). Hydroxychloroquine dose aao Wrong Hydroxychloroquine Dose Is Common, Putting Eyes at Risk., The 2016 American Academy of Ophthalmology Hydroxychloroquine Dosing. Can i take a multivitamin with plaquenil Daily dose greater than 400 mg or, in people of short stature, a daily dosage over 6.5 mg/kg ideal body weight or total cumulative dose of more than 1,000 g ; medication use longer than five years ; concomitant renal or liver disease because the drug is cleared by both routes underlying retinal disease or maculopathy ; age greater than 60 years. Hydroxychloroquine-Induced Retinal Toxicity - American.. Plaquenil hydroxychloroquine sulfate dosing, indications.. Hydroxychloroquine Plaquenil Toxicity and Recommendations for Screening. Mar 08, 2017 The ACR 2016 statement goes on to note that other authors have recommended a dosage of 6.5 mg/kg of actual body weight but capped at 400 mg/day and adjusted for renal insufficiency, and the ACR statement stops short of specifying which dosage strategy it recommends. “The AAO recommendations are much more definitive and state more specifically what screening is recommended and what is a safe dosage,” commented Dr. Rosenbaum. Dosage. The 2002 recommendations considered a daily dose at or below 6.5 mg/kg/day of hydroxychloroquine to be low-risk for subsequent toxicity. Hydroxychloroquine is dispensed in 200 mg tablets, so an “average” 70-kg patient using the common dose of 200 mg bid actually would be receiving a slight overdose according to this threshold. Ongoing treatment 400mg hydroxychloroquine salt 310mg base taken once weekly. Post-exposure prophylaxis Loading dose 800mg of hydroxychloroquine salt 620mg base taken at 0-hours, then 400mg 310mg base taken at 6-hours, 24-hours, and 48-hours. Ongoing treatment 400mg hydroxychloroquine salt 310mg base taken daily for 12 days.