It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Hydroxychloroquine pulmonary fibrosis Chloroquine dose for lupus Plaquenil is the devil! Worked well 1st 2 mts. After that I had issues with my vision, felt waves of nervousness, and extreme anxiety where I started to question my sanity. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. I have had chronic, clinical depression my entire life which I am on meds for. The Plaquenil GREATLY effected by depression. I am no longer taking it. If you Google 'Plaquenil Depression' you will see that it has this effects on others. That's how I got to this post! Hopefully there is something else I can try to deal with my symptoms. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Plaquenil depressed Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria, Plaquenil Hydroxychloroquine - Side Effects, Dosage. Hydroxychloroquine effects on folliculitis decalvansPlaquenil medicine side effectsEye plaquenil screeniingHydroxychloroquine side effects heart ef 25 With Plaquenil Plaquenil is manufactured in only a 200 mg tablet The typical dosage is either 200 or 400 mg per day 200 mg daily puts anyone under 68 pounds at risk1 400 mg of Plaquenil daily puts anyone under 135 pounds at a higher risk for toxicity Therefore, 200mg of Plaquenil daily is going to be a safe dosage for virtually all adults13 Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy. Can Plaquenil cause Major Depression? - Treato. PLAQUENIL Side Effects, Reviews by Patients -. I have RA and have been on Plaquenil for 18 months and it has worked really well in controlling my pain. This is a serious drug, so I did research, but never ran across this side effect. Now I'm so.depressed that I feel as if I'm heading towards a nervous breakdown. I've lost interest in everything! This is not me! After several months off of plaquenil, I went back on it, deciding to stick with the 100 mg per day. I have always been very sensitive to meds. Again my fatigue improved and I began to be able to do more. But again- over several months time my anxiety, depression, and sense of distance from personal relationships began to worsen. Dosage for Plaquenil. The adult dose of Plaquenil to suppress malaria is 400 mg on the same day each week. The pediatric weekly suppressive dosage is 5 mg/kg of body weight. The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days.