It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. Hydroxychloroquine dyschromia Hydroxy chloroquine What if plaquenil doesn't work for lupus Hydroxychloroquine plaquenil and sulfasalazine azulfidine are used for mild rheumatoid arthritis. they are not as powerful as other dmards, but they usually cause fewer side effects. Plaquenil takes quite a long time to get to its peak effectiveness depending on what you read, anywhere from 3 months to a year. Unless you are having significant side effects, try to give it at least 6 months before you decide it doesn't work for you. I am a 72 year old female, diagnosed with RA 6 years ago. I took Plaquenil 200x2 from 2012-2016, along with Prednisone to start. Due to the fact, I could not use my hands because of the swelling, I risked the possible vision problems. By 2012, symptom free and still fearful of vision loss, I stopped the drug. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. It may be as long as 12 weeks before you notice the benefits. What to use when plaquenil and sulfasalazine doesn't work Rheumatoid Arthritis Drug Treatments Pros and Cons., PLAQUENIL" Rheumatoid Arthritis Community - Support Group Plaquenil and the fluPlaquenil ringing in earsCan hydroxychloroquine be taken with humiraHydroxychloroquine mnemonic Aug 22, 2006 Optimal use of disease‐modifying antirheumatic drugs DMARDs in rheumatoid arthritis is vital if progression of disease is to be reduced. Methotrexate MTX and sulfasalazine SASP are widely used inexpensive DMARDs, recently often combined despite no firm evidence of benefit from previous studies. Combination therapy with sulfasalazine and methotrexate is.. Plaquenil User Reviews for Rheumatoid Arthritis at. Sulfasalazine User Reviews for Rheumatoid Arthritis at. Three anti-malarial drugs are prescribed for lupus symptoms. Hydroxychloroquine Plaquenil is the most commonly prescribed because it is generally believed to cause fewer side effects; chloroquine Aralen has a reputation for more serious side effects, but it may be prescribed in situations where hydroxychloroquine cannot be used. My question is for those that have taken Plaquenil/Hydroxychloroquine. How long did it take for it to remove symptoms in your personal experience? I know I've read it can take up to 6 months but what I'm wondering is, do you just wake up one day and find it's kicked in 6 months down the road or more likely, it starts to work slowly over 6 months? Rheumatoid arthritis is a chronic disorder for which there is no known cure. Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients.