How common is chloroquine retinopathy

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  1. DoniLeoni XenForo Moderator

    How common is chloroquine retinopathy


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine retinopathy, is a form of toxic retinopathy damage of the retina caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs. Introduction Chloroquine and its derivatives are being widely used today for the treatment of such diseases as disseminated lupus erythematosus, discoid lupus, light sensitivity eruptions, sarcoid, asthma, skin tumors, rheumatoid arthritis, and other collagen diseases. Corneal changes were noted soon after the introduction of these drugs, and have been well documented in the literature. 1-14. Some patients, toxicity may first present as pericentral retinopathy and thus requires screening outside the macula. We assume chloroquine retinopathy follows a similar course as hydroxychloroquine retinopathy and so these guidelines also apply to patients taking chloroquine therapy.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    How common is chloroquine retinopathy

    Retinal Physician - Hydroxychloroquine Maculopathy An Update on., Chloroquine Retinopathy A Report of Eight Cases with ERG.

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  4. Hydroxychloroquine and Chloroquine Retinopathy is the first single-source book on the subject and is essential for the practicing ophthalmologists, rheumatologists, dermatologists, and internists who prescribe these drugs. It covers clinical topics such as signs and symptoms of toxicity, toxicity screening, ancillary testing, to whom and why.

    • Hydroxychloroquine and Chloroquine Retinopathy David J..
    • Hydroxychloroquine and Chloroquine Retinopathy..
    • Chloroquine and Hydroxychloroquine Toxicity Practice..

    Chloroquine Aralen is used for preventing and treating malaria and amebiasis, an infection of the intestines caused by a parasite. Common Side Effects of Chloroquine. Retinopathy is a well-characterized side effect of treatment and includes cotton-wool spots, intraretinal and pre-retinal hemorrhage, and macular edema See Figure 3. A wide incidence range of 18 percent to 86 percent has been reported for interferon retinopathy. 24 Signs develop within two weeks to three months of treatment onset; patients may complain of blurred vision or be entirely. The most common type has a bull's-eye appearance and consists of a sharply defined, doughnut-like zone of atrophic pigment epithelium surrounding a central homogeneous darker area see Fig. 64-6. This pattern is reminiscent of that seen in the macula of patients with chloroquine retinopathy Fig. 64-7.

     
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